Application Specific LC Systems

Shimadzu offers a wide range of pre-configured application specific liquid chromatography systems. In detail these are:

  • i-Series Method Transfer System

The i-Series Method Transfer System (MT system) enables both conventional analysis via its high compatibility with existing LC systems and rapid analysis via high-speed methods. In pharmaceutical development, a single integrated system allows process synthesis screening analysis for synthetic substances in the UHPLC flow line, and impurity content identification in the HPLC flow line. Read more

  • Catechin Analysis Kit

The National Agriculture and Food Research Organization (NARO) and Shimadzu have been investigating fast, convenient, and accurate methods for analyzing foods’ functional components for its research and social implementation purposes. This kit provides the validated test method from sample pretreatment through a run of HPLC, developed in cooperation with NARO, for measuring the catechins in tea leaves. Reliable catechin values can be easily obtained, and the quantitative results are shown immediately in a report. This kit strongly supports data acquisition required for applications and the development of functional foods, and can even be used for quality control of tea products. Read more

  • Co-Sense for Impurities

The FDA draft guidance, “Genotoxic and Carcinogenic Impurities in Drug Substances and Products: Recommended Approaches” prescribes permitted limits for genotoxic impurities in drug substances. These impurities demand more sensitive trace-level analysis than normal impurities. Generally, mass spectrometry methods, such as GC/MS or LC/MS, are used for the high-sensitivity analysis of impurities. However, there is increasing demand for the establishment of a high-sensitivity quantitation method using an absorbance or other conventional detector that is easy to operate and can easily apply existing LC analysis conditions. Read more

  • Co-Sense for LC-MS

In LC-MS, there are various factors which may preclude the applicability of HPLC with MS analysis, including the interference associated with non-volatile buffers often used in HPLC. Therefore, tedious procedures are adopted, in which separation and collection is conducted by HPLC, and after desalting and other processing, MS measurement is performed. Co-Sense for LC-MS automates the entire process of separating and purifying the target compounds from the sample, including the processes of purifying, concentrating, and desalting. This eliminates the need to select HPLC mobile phases to accommodate subsequent measurement using LC-MS. Read more

  • Co-Sense for BA (Bio-sample Analysis)

HPLC is widely employed in the analysis of drugs within bio-samples. Conditions of the sample pretreatment, as well as chromatographic conditions, are important factors that significantly affect the accuracy and sensitivity of the analysis. Co-Sense for BA, with its unique configuration comprised of the newly developed MAYI-ODS on-line SPE column and the on-line dilution flow channel, automatically and seamlessly conducts all processes from sample pretreatment to analysis. On-line pretreatment of bio-samples such as blood serum or plasma will remarkably enhance the efficiency, as well as reduce the labor, of the analysis. Read more

  • Antimicrobial Screening System

Screening of 24 Synthetic Antimicrobial Compounds That Remain in Meat Synthetic antimicrobial agents are used as animal drugs and feed additives and they are known to remain in the body of farm animals. Residue limits prescribing the safe ingestible amounts of such agents have been set so that people can safely eat meat and processed meat products. Thanks to a pretreatment method* that minimizes the influence of impurities in meat (beef, pork, and chicken muscle), LC system enables screening of 24 synthetic antimicrobial compounds, which are regulated in Japan, Europe, and other regions, remaining in meat. Read more

*: Consumables for pretreatment are not included in the package. They need to be provided by the customer.

  • Nexera Amino Acid Analysis System

Amino acid analysis occupies an important role in diverse fields such as food science and pharmaceutical manufacturing. Nexera Amino Acid Analysis System uses detection by post-column fluorescence derivatization, with o-phthalaldehyde (OPA)/N-acetylcysteine as the reaction reagents, to selectively and with high sensitivity quantitate the amino acids contained in samples with high levels of contaminants. Read more

  • Reducing Sugar Analysis System

The Nexera reducing sugar analysis system uses Shimadzu’s unique post-column boric acid-arginine fluorescence derivatization method. This system reduces the effects of impurities and offers both high sensitivity and a wide dynamic range. As a result, sugars contained in samples can be analyzed simultaneously, without any dilution even in the case of significant concentration differences. Read more

  • Nexera Organic Acid Analysis System

The Nexera Organic Acid Analysis System has been well-received in the fields of food and environment as a highly selective high-sensitivity system. It uses separation by ion exclusion chromatography and Shimadzu’s unique detection technique (pH-buffered electric conductivity detection). Recently, this system is being utilized by even more users in a wide variety of fields, and its usage in the fields of pharmaceuticals and life science is increasing. Read more

  • Mycotoxin Screening System

Mycotoxin (mold toxin) is a generic term for metabolites produced by molds on food products that are hazardous to human and animal health. To improve food safety, food processors have been inspecting ingredients for the presence of such mycotoxins. In only 14 minutes, this mycotoxin screening system can detect the presence of 10 mycotoxin components with high sensitivity at concentration levels specified by EU standards, which are the strictest in the world. Furthermore, because the system does not involve a sample derivatization process, samples can be measured much more efficiently. Read more

  • Nexera-e

Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved. The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products, and synthetic polymers. Read more

  • Co-Sense Series

The Co-Sense series features automatic sample processing systems intended to improve the efficiency of LC-MS operations by automating complicated sample processing steps. This eliminates the need for tedious, time-consuming, and expensive manual processes. It also achieves parameter settings for separating target components by HPLC can be set freely without being encumbered by LC-MS limitations. The Co-Sense series is especially well suited to the structural analysis of impurities in pharmaceuticals. It is also advantageous for LCMS measurement in the life sciences or chemical industry fields, such as to research metabolites in biological organisms or to analyze the side reaction in chemical synthesis. Read more

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