Ensuring steroid-free food supplements

Ensuring steroid-free food supplements – Shimadzu News 02 / 2020

Identification of steroids in pharmaceuticals and food supplements with LCMS-8045

Authors: Dr. Gerasimos Liapatas & Dr. Manos Barbounis (Applications Department of N. Asteriadis S.A.)

Anabolic steroids are often encountered in samples of nutritional supplements and pharmaceutical preparations, either due to doping-related activities [1] or cross-contamination issues during production [2].
Developing methods to identify steroids in such samples can be challenging, since the method should be able to monitor numerous steroids with large differences in terms of polarity.


Compounds to be monitored comprise relatively polar steroids such as anastrozole as well as low polarity steroid esters which have been occurring with increasing frequency in food supplement samples.
The method developed includes testing for testosterone caproate and testosterone isocaproate, a challenging set of isomers which were partially separated (Resolution 0.6 as per Eur.Ph.) enabling the analytical method to identify which of the two isomers is contained in the sample. With respect to tibolone, three MRM transitions are reported with no need to resort to derivatization, which is usually the case with tibolone and its metabolites. Finally, a comprehensive rationale is provided for choosing MRM transitions for steroid esters, based on fragments of the free steroid read the full article on Shimadzu’s News 02/2020 p.11-13 …

Antec Scientific – Azithromycin a treatment for COVID-19?

Azithromycin a treatment for COVID-19?

Antec Scientific contribution to the treatment of COVID-19 with Azithromycin

Leiden, NL (8. April 2020). You may be wondering what Antec Scientific ALEXYS™ Antibiotics Analyzer has to do with the coronavirus SARS-CoV-2 first occurred in Wuhan, China, causing a worldwide pandemic respiratory disease COVID-19.
As a matter of fact secondary bacterial infections (co-infections, superinfections) are a major risk factor for adverse COVID-19 outcomes.  A recent study from China published in the Lancet (Zhou et al., 2020) found that 27 out of 28 patients with bacterial co-infections died (96%). Staphylococcus aureus is the main cause of secondary infections in influenza but Streptococcus pneumoniae and Haemophilus influenzae are also commonly found, although it is not yet known which pathogens are associated with secondary infections in COVID-19, except for the known Acinetobacter Baumannii, a typically hospital acquired (nosocomial) infection.
Almost all hospitalized patients receive immediately empirical antibiotic treatment to strengthen the immune system and to reduce further complications by ventilation associated bacterial co-infections and to reduce mortality. Azithromycin is one of the antibiotics that has been widely applied for light as well as heavily infected COVID-19 patients (China, Italy, Spain and now worldwide). In a new French study published in Intl. Journal Antimicrob Agents (Gautret et al., 2020), early evidence was also found that the combination of hydroxychloroquine, a popular anti-malarial drug and antibiotic azithromycin could be especially effective in treating the COVID-19 coronavirus and reducing the duration of the virus in patients.

https://antecscientific.com/news

UV-Vis analysis on the next level

UV-Vis analysis on the next level

Six new UV-i Selection UV-VIS spectrophotometer models 

Multi-faceted increase in efficiency 

UV-1900i: awarded system with new functionalities

 

Shimadzu, one of the world leaders in analytical instrumentation, has released six new UV-VIS spectrophotometer models under a new UV-i Selection brand. These instruments are equipped as standard with the LabSolutions UV-Vis analytical data system for UV-VIS spectrophotometers. The UV-i Selection systems are well-suited for use in a wide range of fields, including academia, pharmaceuticals and chemicals. They offer a highly user-friendly operability, automated analysis of multiple samples and other features to satisfy a broad spectrum of customer needs.

The six models in the UV-i Selection series are the UV-1900i, UV-2600i, UV-2700i, UV-3600i Plus, SolidSpec-3700i and SolidSpec-3700i DUV. The letter “i” stands for

  • the “intelligence” to determine automatically whether samples pass or fail criteria, relieving users from the tedium of repetitive quality control steps
  • “innovation” covering automatic measurement to improve operating efficiency
  • “informatics” meaning improved data analysis efficiency and stronger data management functionality.

View Details …

Release of JEM-ARM300F2 (GRAND ARM™2)

Release of a New Ultrahigh Atomic Resolution Analytical Electron Microscope

Release of JSM-F100

The next level of analytical intelligence in FE-SEM for combining high resolution and operability

Oxford – Introducing new range of SEM-EDS detector with Xplore

Oxford Instruments, the global leader in microanalysis systems, is proud to announce that its NanoAnalysis division has launched the compact Xplore Silicon Drift Detector (SDD) for the electron microscope

Oxford – AZtecTEM: The next generation of EDS for TEM

Oxford Instruments, the global leader in nanoanalysis systems, is proud to introduce AZtecTEM with Ultim® Max for TEM, to once again transform the capability and use of EDS on the transmission electron microscope.

AZtecTEM, powered by Ultim Max, delivers unparalleled EDS performance on the transmission electron microscope (TEM). Ultim Max delivers up to a 3x increase in sensitivity compared to previous generation SDD detectors. This combined with a 4x increase in detector speed opens up new applications for EDS in the TEM including biology and in situ live chemical analysis.

High sensitivity, and high-speed Ultim Max EDS detectors allow the use of AZtecLive in a TEM for the first time. AZtecLive combines live X-ray maps, electron images and X-ray spectra allowing real-time feedback of chemistry changes when specimens are exposed to heat, liquids, gases or electrical fields. This enhanced functionality will change the way in situ experiments in the TEM are performed. This will allow users to re-evaluate the way they design advanced materials and understand the reactions that underpin clean energy.

AZtecTEM uniquely quantifies elemental composition by mass thickness. This delivers more accurate quantification across the entire range of specimens analysed in a TEM and critically allows users to measure the thickness of their specimens using EDS alone, opening up an entire new dimension of measurement.

According to TEM Product Manager, Dr. Samuel Marks, the new range of detectors will offer new capability and productivity for currently challenging fields of analysis. “The sensitivity of Ultim Max detectors for TEM combined with new AZtecLive technology will transform the way customers understand chemistry as it happens in the TEM. This will open up a new range of applications for elemental analysis.”

SHIMADZU – NEW Nexera Series

Shimadzu’s New Nexera UHPLC Series with AI and IoT Enhancements Sets Industry Standard for Intelligence, Efficiency and Design

Shimadzu Corporation announces the release of the Nexera Ultra High-Performance Liquid Chromatograph series, incorporating artificial intelligence as Analytical Intelligence, allowing systems to detect and resolve issues automatically. The Nexera series makes lab management simple by integrating IoT and device networking, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.

The Nexera UHPLC series maximizes reliability and uptime with fully unattended workflows that span from startup to shut-down. Operators can set the Nexera to start up at a specified time, so that it can complete auto-purge, equilibration, baseline checks and system suitability in advance, and be ready for analysis before they arrive at the lab. In addition, FlowPilot ramps up the flow rate gradually, reducing the possibility of damage to columns. The Nexera also has auto-diagnostics and auto-recovery capabilities that allow it to monitor pressure fluctuations to check for anomalies.

With remote mobile phase monitoring and integrated consumables management, the system maximizes uptime and reliability. Real-time monitoring of mobile phase levels allows lab personnel to efficiently run batches and respond accordingly if there isn’t enough mobile phase before starting a run. In addition, Nexera tracks consumable usage and sends alerts when parts need replacing, allowing users to keep the system running at peak performance. The Nexera UHPLC series allows analysts to confirm parameters and monitor chromatograms in real time directly from a web browser on their smart device.

The Nexera’s elegant, compact design saves valuable bench space. Because it uses over 80% less electricity when on standby, it significantly reduces running costs and supports an environmentally-friendly lab.

Key components of the Nexera UHPLC series include:

  • Mobile Phase Monitor MPM-40
  • System Controller SCL-40, CBM-40
  • Absorbance Detector SPD-40 / SPD-40V and Photodiode Detector SPD-M40
  • Solvent Delivery Unit LC-40 series
  • Autosampler SIL-40 series / PLATE CHANGER
  • Column Oven CTO-40 series

For more details, visit Nexeraseries.com

Shimadzu’s New GC/MS Forensic Toxicological Database V2

Screening for Forensic Chemicals for the Purpose of Specifying the Causes of Intoxication and Verifying Drug-Related Crimes
Shimadzu’s New GC/MS Forensic Toxicological Database Ver.2

Shimadzu – New “AP225W” Semi-micro Analytical Balance

Shimadzu announces the release of its “AP225W” semi-micro analytical balance. While being capable of measuring up to 220 g, it also features a minimum reading of 0.01 mg (1/100,000th of a gram).

This high-end model completes measurements in approximately two seconds, and can measure up to 220 g on the order of 0.01 mg. Using the standard attachment “AP holder”, a measuring flask or test tube can be held in a tilted position. Moreover, incorporating the optional “STABLO-AP” ionizer on the main unit will quickly eliminate static electricity charged on the container and sample, thus enhancing the reliability of measurements. Connecting the AP225W to the “LabSolutions Balance” measurement data management system enables an environment that complies with various standards.

More …