Pioneering Non-Destructive Same-Cell Technologies
Cytosurge is a Swiss high-tech company at the forefront of single-cell technologies, uniquely combining microfluidics with Atomic Force Microscopy (AFM) to enable an entirely new way of interacting with living cells. Through this powerful technological integration, Cytosurge has created a platform that allows ultra-precise, non-destructive manipulation of individual cells, opening new possibilities in basic research, biotechnology and drug discovery.
Through this powerful technological integration, Cytosurge has created the FluidFM OMNIUM platform, a system that allows ultra-precise, non-destructive manipulation of individual cells. This unlocks the power of Same-Cell analysis, enabling researchers to study the evolution of one specific cell over time, rather than just a snapshot.
With its roots in Switzerland and a strong presence in leading academic institutes and research centers worldwide, Cytosurge’s mission is to provide scientists with tools that enable true insight and control. Its technology makes it possible to inject, extract and mechanically characterize living cells with nanometer-scale precision, without compromising cell viability.
The FluidFM® OMNIUM Platform
At the core of Cytosurge’s portfolio is the FluidFM OMNIUM platform, a highly automated cell manipulation system that merges AFM with microfluidics.
The heart of the system is a specially engineered FluidFM cantilever — a hollow AFM probe that can transport liquids and biomolecules through an internal microchannel while simultaneously measuring mechanical forces at the nanonewton scale. This enables researchers to:
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inject DNA, RNA, proteins, or drugs into individual living cells,
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extract cytoplasmic biopsies for Live-seq (transcriptome analysis) without killing the cell,
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measure mechanical properties such as stiffness, adhesion and elasticity,
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revisit the same cell at multiple timepoints to track dynamic changes.
How It Works
The FluidFM OMNIUM integrates a high-precision AFM, microfluidic pressure control and dedicated software into one coherent platform.
The workflow is designed for ease of use: the user simply clicks on target cells, and the automated system takes over positioning the FluidFM probe to measure forces or gently penetrate the membrane to inject or withdraw material.
This allows researchers to work at the true single-cell level, avoiding the loss of information that occurs when averaging over large cell populations.
Applications and Use Cases
The OMNIUM FluidFM® System is widely used in cutting-edge applications such as:
- Live-seq & Same-Cell Analysis (Temporal monitoring of the same cell),
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CRISPR-based cell line development,
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cancer and stem cell research,
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drug discovery and screening,
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synthetic biology,
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cell mechanics and biophysics.
Superior Gene Editing & CRISPR Workflows: In CRISPR and cell line development, the FluidFM OMNIUM offers a distinct advantage over conventional microinjection, electroporation, or bulk transfection methods. It provides absolute control over the stoichiometry and exceptionally gentle interaction, enabling the direct editing of individual cells in a non-destructive manner – even allowing for multiplex editing in a single step. This capability is the foundation of CellEDIT, Cytosurge’s custom gene-editing service, which delivers engineered, monoclonal cell lines for researchers who prefer to outsource complex editing tasks.
Why Cytosurge Stands Out
Cytosurge has transformed cell manipulation from a specialized technique into a practical, everyday laboratory tool. With a strong scientific foundation, Swiss-grade engineering, and the unique capabilities of proprietary FluidFM® technology, the company delivers solutions that allow scientists to interact with life at its most fundamental level.
The OMNIUM FluidFM® OMNIUM Platform is now regarded as one of the most advanced platforms for anyone working in modern cell biology, biotechnology, and therapeutic development, enabling a new generation of precise, reproducible and non-destructive cell experiments that unlock the power of Same-Cell analysis.