The ROXY™ Exceed is a new generation Potentiostat dedicated for coupling Electrochemistry with MassSpectrometry(EC-MS). In on-line mode the ROXYExceed can be used in direct infusion mode, for flow injection analysis, or with any type of LC-MS system. Applications and publications are available for using the ROXY in top-down or bottom-up LC-MS proteomics. In off-line mode the ROXYExceed is mainly used for electrochemical synthesis and for the collection of electrochemically generated products. Collected fractions are used for further analysis.