iMLayer™ AERO

iMLayer™ AERO – Automatic Sprayer for High-Sensitivity MALDI Imaging

Shimadzu introduces the iMLayer™ AERO, an advanced automatic sprayer designed for MALDI imaging that ensures high sensitivity, spatial resolution, and reproducibility. By incorporating a precisely controlled sample stage that maintains a consistent distance from the spray nozzle, the iMLayer™ AERO enables stable matrix deposition, resulting in superior MALDI-TOF MS imaging performance.

Key Features and Benefits

• Stable and Reproducible Matrix Spraying: The controlled movement of the sample stage allows uniform deposition of fine matrix crystals, significantly enhancing both sensitivity and spatial resolution.
• Humidity-Controlled Environment: Unlike traditional hand-spraying methods, the iMLayer™ AERO eliminates humidity-related inconsistencies by replacing the atmosphere inside the spray chamber before pretreatment. This ensures stable spraying conditions, regardless of environmental humidity levels.
• Clog-Free Reagent Delivery for Consistency: A built-in rinsing mechanism prevents matrix clogging at the nozzle tip, maintaining a stable and reproducible spray, which is crucial for MALDI mass spectrometry analysis.
• Enhanced Spray Performance: The standard protocol delivers homogeneous matrix application while providing sensitivity levels comparable to hand spraying, but with improved resolution and reproducibility.
• Two-Step Vapor Deposition for Ultra-High Resolution Imaging: To achieve high spatial resolution (5-10 µm) images and maximize sensitivity, the iMLayer™ AERO can be combined with Shimadzu’s iMLayer matrix vapor deposition system. This unique two-step vapor deposition method is an exclusive capability available only through Shimadzu’s sample preparation solutions.

Advanced Workflow for High-Quality MALDI Imaging

The iMLayer™ AERO simplifies the sample preparation process for MALDI imaging, ensuring that scientists and researchers can generate high-quality, reproducible imaging data with ease. By integrating automatic, precise matrix deposition, it eliminates inconsistencies often associated with manual spraying, making it an indispensable tool for MALDI-TOF MS imaging.

For more information about its features and specifications, please visit the official Shimadzu website.