DynaPro Series

Wyatt Technology’s suite of Dynamic Light Scattering (DLS) instruments offers advanced solutions for the characterization of nanoparticles and macromolecules in solution. These instruments provide precise measurements of particle size, molecular weight, particle concentration, and zeta potential, catering to a wide range of applications in biophysics, biochemistry, and material science.​

DynaPro™ Plate Reader III

The DynaPro Plate Reader III is designed for high-throughput, automated DLS measurements directly within industry-standard microwell plates (96-, 384-, or 1536-well formats). This in situ analysis eliminates the need for fluid transfer, enhancing efficiency and reducing sample handling errors. Key features include:​

• Broad Measurement Range: Capable of detecting hydrodynamic radii from 0.5 nm to 1000 nm.
• Molecular Weight Determination: Measures weight-average molar mass from 1 to 1000 kDa.
• High Sensitivity: Detects sizes down to 0.125 mg/mL lysozyme concentration.
• Temperature Control: Supports temperature ramps from 4 °C to 85 °C, facilitating studies on thermal stability and aggregation.​
• Automation Integration: Seamlessly integrates with liquid-handling robots for fully automated workflows, enhancing productivity in high-throughput environments.

The Plate Reader III is particularly suited for applications such as assessing protein aggregation, optimizing biotherapeutic formulations, screening inhibitors, and refining protein crystallization conditions.

DynaPro™ NanoStar™ II

The DynaPro NanoStar II offers traditional cuvette-based DLS measurements with enhanced capabilities. It is adept at analyzing size distributions and particle concentrations of various samples, including proteins, nanomedicines, viruses, vesicles, emulsions, micelles, and metallic nanoparticles. Distinctive features encompass:​

• Dual Detection Channels: Incorporates two optimized 90° detection channels—one for DLS and another for static light scattering (SLS)—enabling comprehensive analysis of molecular interactions and structures.​
• Minimal Sample Volume: Performs accurate measurements with as little as 2 µL of sample, conserving valuable reagents.​
• User-Friendly Interface: Features an intuitive touchscreen application for straightforward operation, suitable for both novice and experienced users.​
• Temperature Versatility: Offers a temperature control range from -10 °C to +120 °C, accommodating a variety of experimental conditions.​

The NanoStar II is ideal for detailed studies requiring precise measurements of small sample volumes under varying thermal conditions.​

DynaPro™ ZetaStar™

The DynaPro ZetaStar is a versatile instrument capable of performing dynamic, static, and electrophoretic light scattering measurements. It supports both manual operations using microcuvettes and automated analyses via an autosampler, providing flexibility for different laboratory workflows. Notable features include:​

• Comprehensive Measurement Capabilities: Simultaneously assesses size distribution, particle concentration, molecular weight, turbidity, and zeta potential, offering a holistic view of sample characteristics.​
• Advanced Optical System: Employs parallel, optimized optical channels for enhanced sensitivity and accuracy in detecting scattered light.
• FIDELIS™ Technology: Utilizes a solid-state interferometer for precise electrophoretic mobility measurements, improving data quality and reproducibility.
• Flexible Sample Handling: Accommodates a range of solvents, including those with salt concentrations exceeding physiological levels, making it suitable for diverse applications.​
• Temperature Control: Maintains sample temperatures between -10 °C and +120 °C for DLS and SLS measurements, and between 4 °C and 70 °C for electrophoretic light scattering (ELS), ensuring consistent experimental conditions.​

The ZetaStar is particularly valuable for analyzing proteins, nanomedicines, viral vectors, extracellular vesicles, nanoemulsions, and polymers, providing critical insights into their physicochemical properties.

Feature Comparison

These instruments are engineered to meet the rigorous demands of modern research and development, providing reliable and accurate data essential for advancing scientific understanding and technological innovation.

For further information about their features and specifications, please visit the official WYATT website.