With the UP400St (400W, 24kHz), the serial of Hielscher’s digital ultrasonic devices is expanded by a powerful 400 watts ultrasonicator. The new UP400St is the successor of UP400S – one of Hielscher’s most popular lab systems. Its high ultrasound power and robustness make the UP400St perfectly suitable for the use in demanding environments. Equipped with a colored touch screen for easy controllability, integrated LEDs for sample illumination, pluggable temperature sensor, integrated SD-Card for automatic data recording, as well as many other features, the UP400St convinces by its user-friendliness and reliability. The UP400St is ideal for efficient and precise sonication of larger samples. Being our most powerful laboratory device, the UP400St is suitable to fulfil various applications such as homogenizing, emulsifying, dispersing, deagglomeration & wet-milling (particle size reduction), cell disruption & disintegration, extraction, degassing, as well as sonochemical processes. With sonotrodes of a diameter range from 3 to 40mm, the device is suited for the sonication of sample volumes from 5 to 4000ml. In combination with a flow cell approx. 10 to 50 liters per hour can be sonicated. When used for sample preparation, the UP400St is mainly used for bigger volumes. It is suited for the development of ultrasonic applications in the laboratory, but also in the bench top optimization as well as for the production of small quantities. The device functions and the various accessories allow for different applications and the coverage of very wide parameter configurations. The UP400St convinces as a powerful and reliable ultrasonic homogenizer: It can be operated continuously 24h/7d under full load and is good for processing up to 400L/h. Generally, the UP400St is used for the sonication of volumes from 5.0 to 4000mL. Due to its robustness and its capability to run 24/7, the UP400St can be also used for the production of smaller quantities. For production processes, the sonication is mostly carried out in a continuous flow-through system with a flow cells and a sonotrode with sealing for the flow cell reactor. In combination with the flow cell FC22K, the material can be sonicated in a continuous flow-through mode, e.g. at a flow rate of 20 to 200mL per minute (the final capacity depends on the application). The stainless steel flow cell is pressurizable up to 5 barg and is equipped with a cooling jacket. By this, inline ultrasonication processes can be simulated in smallest scale.